Day 2 :
Jaleel Kareem Ahmed has expertise in evaluation in iron and steel industry. He has registered 3 patents in USA, UK and Iraq about using water in iron industry and wax for storage and transportation direct reduced iron (DRI) and using wax for carburizing of steel. In 2013, he was awarded Scientific Medal from Iraqi Government. He has been serving as a Reviewer of Journal of Advances in Polymer Technology, Thomson Reuters.
A case study is carried out on urine of a 40 years old man. Two urine samples are taken from the urine system one after drinking concentrated red beet juice (mechanically extracted) and the second one before drinking. Ultraviolet visible absorption spectra measurements done, the results show that with concentrated juice the absorption bands are shifted toward low energy due to the hydrogen bond formation by exchangeable proton from the juice (anthocyanin pigments) to the lone pair of electrons on the oxygen and nitrogen atoms in uric acid and urea and vice versa which shifted the n- π absorption band to the lower energy, while diluting the above sample spectrum shows shifting to the higher energy, this is due to the low hydrogen bond formation with uric acid and urea due to the low concentration of exchangeable proton upon dilution, as water is a good hydrogen bonding competitor. From ultraviolet visible spectra we conclude that absorption band shifted to the lower energy with drinking concentrated juice and to the higher energy with diluted one which reflects the importance of concentration of the juice on hydrogen bonding formation and on the enhancing of detoxification of uric acid and urea from the blood, thus we recommended high concentration juice which can obtain from red beet (highest concentration of anthocyanin than other fruit). Dilution of pure urine sample was not effected its spectrum this is because already water present in urine in a good quantity comparing with uric acid and urea concentrations thus no effect for more water. Results show that with drinking high concentrated red beet juice the viscosity, electrical conductivity and refractive index of exit urine are decreased, this enhance detoxification process the viscosity of urine with juice lower than viscosity of pure water which is 1.00 cP at 20 oC makes urine+juice more easy to flow through urine system than water alone. The pP of urine after drinking the juice is increased due to the capture of the proton of uric acid by anthocyanin which is less acidic than former. The increase of pP results in lessens the tension of the human. The density of the urine increases slightly due to the more hydrogen bonding formation with the anthocyanin which results in reducing the volume of the unit weight of the sample.
- Structural Biochemistry | Cardiac Biochemistry | Clinical and Nutritional Biochemistry
Jaleel K Ahmed
University of Babylon, Iraq
Ahmadi Hospital, Kuwait
Ali Saad is currently a Specialist of Anesthesia and Intensive Care Unit, working in field for 12 years’ with continuous medical education programs, courses with weekly presentations.
Statement of the Problem: Evidence is representing that non-anesthesiologist-administered propofol (NAAP) sedation has a safety and efficacy profile comparable or superior to that provided by benzodiazepines with or without opioids. The guidelines currently available emphasize the importance of appropriate patient selection, staff training, monitoring, and low-dose sedation protocols for use safety.
Methodology & Theoretical Orientation: give Propofol with Initial dose: 1.5‑2.5 mg/kg, patient will be apneic within 30‑90 seconds at the infusion rate of 80-120 µg/kg/min.
Conclusion & Significance: It is unlikely that the use of propofol by non-anesthesia professionals will cease. In many ways, propofol may be as safe or safer than more traditional medications. Monitoring must be standardized and adequate. Given their training, experience, and everyday environment, anesthesiologists should be at the forefront to determine protocols, initiate training, perform or oversee competency reviews, and set up quality assurance programs.
Jade K Forwood has completed his BBiomedSc at James Cook University and his PhD in Biochemistry and Molecular Biology at the John Curtin School of Medical Research (Australian National University). He was awarded a University Medal in 1998 and the Frank Fenner Medal in 2002 for most outstanding PhD thesis. In 2007, he has joined the School of Biomedical Sciences at Charles Sturt University to coordinate and lecture in biochemistry.
The assembly and regulation of viral capsid proteins into highly ordered macromolecular complexes is essential for viral replication. Here, we utilize crystal structures of the capsid protein from the smallest and simplest known viruses capable of autonomously replicating in animal cells, circoviruses, to establish structural and mechanistic insights into capsid morphogenesis and regulation. The beak and feather disease virus, like many circoviruses, encode only two genes: A capsid protein and a replication initiation protein. The capsid protein forms distinct macromolecular assemblies during replication and here we elucidate these structures at high resolution, showing that these complexes reverse the exposure of the N-terminal arginine rich domain responsible for DNA binding and nuclear localization. We show that assembly of these complexes is regulated by single-stranded DNA (ssDNA) and provide a structural basis of capsid assembly around single-stranded DNA, highlighting novel binding interfaces distinct from the highly positively charged N-terminal ARM domain.
Shaheed Zulfiqar Ali Bhutto Medical University, Pakistan
Amna Imtiaz has completed her MBBS from University of Health Sciences and MPhil in Hematology from Shaheed Zulfiqar Ali Bhutto Medical University, Pakistan. Currently she is working as a Lecturer in FMDC. She has published 3 case reports in reputed journals.
Aim of study was to correlate serum ferritin with left ventricular function in beta thalassemia major patients with increased transfusion dependence and to find out whether echocardiography can be used to assess pre-clinical cardiac disease in these patients. 60 patients of beta thalassemia major with increased transfusion dependence were enrolled in this study. Serum ferritin levels of all patients were measured by using indirect enzyme linked immunosorbent assay (ELISA). Echocardiography was performed on all patients by a consultant cardiologist by linking conventional echocardiography with tissue Doppler imaging. On the basis of serum ferritin level, patients were divided in to three groups. Group-1 consisted of patients having serum ferritin level equal to or less than 2500 ng/ml, a total of 25 patients were placed in this group. Group-2 included patients having serum ferritin level between 2500 to 5000 ng/ml, a total of 22 patients were placed in this group. Group-3 included patients having serum ferritin level more than 5000 ng/ml and this group consisted of 13 patients. All patients having serum ferritin below 2500 ng/ml had normal systolic function and only 16% of the patients in this group had diastolic dysfunction as reflected by abnormal E/A ratio. In group-3, 27% of the patients had systolic dysfunction reflected by subnormal ejection fraction while 40% of the patients had diastolic dysfunction. In group-3, 62% of the patients had abnormal systolic and diastolic function. Pearson correlation was used to find correlation between serum ferritin and left ventricular function. A strong negative correlation was found which is reflected by a p value of less than 0.05 which is significant. Chi square test is used to correlate serum ferritin with E/A ratio. P value came out to be less than 0.05 which is significant.