Naureen Fatima
Aligarh Muslim University,India
Title: Aloe-Vera leaf extract mediated synthesis of curcumin nanoparticles: Implications in the treatment of Type 2 diabetes in experimental wistar rat model
Biography
Biography: Naureen Fatima
Abstract
Curcumin, an active component of turmeric has caught tremendous attention as a potential therapeutics for diabetes because it is a relatively safe and inexpensive drug that reduces glycemia and hyperlipidemia in rodent models of diabetes.The Streptozotocin (STZ)-induced experimental rat model of diabetes were used to evaluate the effect of in-house synthesized curcumin nanoparticles (Cur NPs) on glycemia, body weight, glycosylated haemoglobin (HbA1c), oxidative stress and inflammatory immunological markers. In this study, we developed Aloe Vera leaf extract (AVLE) mediated curcumin nano-formulation for highly effective diabetes therapy. Polyphenol (AVLE) mediated bio-functional, Cur NPs showed excellent dispersibility and outstanding stability in physiological environments. The data of biochemical and inflammatory biomarkers revealed the ameliorative effect of Cur NPs on STZ-induced diabetic experimental wistar rat model. Interestingly, administration of Cur NPs for 4 weeks was able to prevent body weight loss, reduce the levels of glucose, hemoglobin (Hb), and HbA1C in blood and improve insulin sensitivity.The data of the present study clearly showed that the therapeutic efficacy of the AVLE synthesized Cur NPs were found better than that of free form of curcumin as well as with the AVLE alone. Cur NPs were also found to be effective in ameliorating the increased levels of fasting blood glucose, urine sugar, and urine volume in STZ-induced diabetic rats. Polyphenol mediated green synthesis of Cur NPs with effective and efficacious anti-diabetic potential may open new prospects for type 2 diabetes therapy.