Mihir Y Parmar
Parul University, India
Title: Impact of heat shock proteins in hepatocellular carcinoma
Biography
Biography: Mihir Y Parmar
Abstract
Heat shock proteins are highly conserved proteins, expressed at low levels under normal conditions. Heat shock proteins significantly induced in response to cellular stresses and lead to heat shock response, which could help cancer cells to adapt to stress conditions. As molecular chaperones, heat shock proteins play critical roles in protein homeostasis, apoptosis, invasion and cellular signaling transduction. A heat shock protein over expression is widely reported in many human cancers due to constant stress condition in tumor microenvironment. Heat shock proteins often associated with poor prognosis in many types of human cancers. Up regulation of heat shock proteins may serve as diagnostic and prognostic markers in hepatocellular carcinoma. Targeting heat shock proteins with specific inhibitor alone or in combination with chemotherapy regimens holds promise for the improvement of outcomes for hepatocellular carcinoma patients. In addition, our study suggests progression and challenges in targeting these heat shock proteins as novel therapeutic strategies in hepatocellular carcinoma.